dual targeting of nuak1 and ulk1 using the multitargeted

(9832) GSK-3 (3D10) Mouse mAb - Cell Signaling - CiteAb

Dual targeting of NUAK1 and ULK1 using the multitargeted inhibitor MRT68921 exerts potent antitumor activities. View PDF In Cell Death & Disease on 1 September 2020 by Chen, Y., Xie, X., et al.. Anti-ULK1 antibody (ab240916) AbcamChen Y et al. Dual targeting of NUAK1 and ULK1 using the multitargeted inhibitor MRT68921 exerts potent antitumor activities. Cell Death Dis 11:712 (2020). PubMed:32873786; Shelkovnikova TA et al. Antiviral Immune Response as a Trigger of FUS Proteinopathy in Amyotrophic Lateral Sclerosis. Cell Rep 29:4496-4508.e4 (2019).

Citations for 9832 by Cell Signaling Technology - CiteAb

Dual targeting of NUAK1 and ULK1 using the multitargeted inhibitor MRT68921 exerts potent antitumor activities. Curcumin synergizes with 5-fluorouracil by impairing AMPK Dec 22, 2017 · Background Chemoresistance is a major obstacle that limits the benefits of 5-Fluorouracil (5-Fu)-based chemotherapy for colon cancer patients. Autophagy is an important cellular mechanism underlying chemoresistance. Recent research advances have given new insights into the use of natural bioactive compounds to overcome chemoresistance in colon cancer chemotherapy. As one of the multitargeted Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Dual targeting of NUAK1 and ULK1 using the multitargeted inhibitor MRT68921 exerts potent antitumor activities

Dual Targeting of CDK4 and ARK5 Using a Novel Kinase

Multiple myeloma is a fatal plasma cell neoplasm accounting for over 10,000 deaths in the United States each year. Despite new therapies, multiple myeloma remains incurable, and patients ultimately develop drug resistance and succumb to the disease. The response to selective CDK4/6 inhibitors has been modest in multiple myeloma, potentially because of incomplete targeting of other critical Frontiers Targeting Cytoprotective Autophagy to Enhance

  • IntroductionImpact of Inhibiting The Initiation and Nucleation Steps on Cancer TherapiesConclusionAuthor ContributionsFundingConflict of InterestMacroautophagy (referred to as autophagy) was first described in 1966 as a cellular process that occurs at the basal level in all cells (1). Autophagy relies on the formation of double-membraned vesicles known as autophagosomes, leading to the degradation of their cargo, such as damaged proteins or organelles (2). The autophagy process involves more than thirteen autophagy-related (ATG) proteins and requires the following major steps:(i) Initiation, (ii) Nucleation, (iii) Maturation, and (iv) Fusion with l Dual Targeting of CDK4 and ARK5 Using a Novel Multiple myeloma is a fatal plasma cell neoplasm accounting for over 10,000 deaths in the United States each year. Despite new therapies, multiple myeloma remains incurable, and patients ultimately develop drug resistance and succumb to the disease. The response to selective CDK4/6 inhibitors has been modest in multiple myeloma, potentially because of incomplete targeting of other critical Nuak family kinaseDual targeting of NUAK1 and ULK1 using the multitargeted inhibitor MRT68921 exerts potent antitumor activities. Utilizing oxidative stress has recently been regarded as a

    Potent Dual BET Bromodomain-Kinase Inhibitors as Value

    Synergistic action of kinase and BET bromodomain inhibitors in cell killing has been reported for a variety of cancers. Using the chemical scaffold of the JAK2 inhibitor TG101348, we developed and characterized single agents which potently and simultaneously inhibit BRD4 and a specific set of oncogenic tyrosine kinases including JAK2, FLT3, RET, and ROS1. Lead compounds showed on-target Targeting autophagy using natural compounds for cancer Recent advances in using natural products/derivatives to target autophagy for cancer treatment have been systemically reviewed. 18-20 Given the pivotal role of autophagy in cancer therapy, herein, we discuss various phytochemicals that may have the ability to regulate the autophagy-related signaling pathways and provide an in-depth insight The anticancer effects of curcumin via targeting the Jun 01, 2020 · Chemicals derived from plants, such as polyphenols, are known as potential agents in cancer prevention, also as part of cancer treatment according to epidemiological supporting findings and preclinical studies [].Curcumin,1,7-bis-(3-hydroxy-4-methoxyphenyl)-1,6-heptadiene-3,5-dione, is a polyphenol produced from the turmeric rhizome (Curcuma longa L.) and has been used as a common

    Yiran CHEN Beijing Medical University, Beijing

    Dual targeting of NUAK1 and ULK1 using the multitargeted inhibitor MRT68921 exerts potent antitumor activities